New camera chip design allows for optimizing each pixel's timing to maximize signal to noise ratio when tracking real-time visual indicator of neural voltage.
New camera chip design allows for optimizing each pixel's timing to maximize signal to noise ratio when tracking real-time visual indicator of neural voltage.
In experiments described in the study, Zhang and Wilson's team demonstrates how"pixelwise" programmability enabled them to improve visualization of neural voltage"spikes," which are the signals neurons use to communicate with each other, and even the more subtle, momentary fluctuations in their voltage that constantly occur between those spiking events.
In recent years, neuroscientists including co-senior author Ed Boyden, Y. Eva Tan Professor of Neurotechnology in BCS and The McGovern Institute for Brain Research and a Picower Institute affiliate, have worked to meet that need by inventing"genetically encoded voltage indicators" , that make cells glow as their voltage changes in real-time.
Moreover, the pixelwise chip detected neural spiking activities that the conventional sensor missed. And when the researchers compared the performance of each kind of sensor against the electrical readings made with a traditional patch clamp electrode, they found that the staggered pixelwise measurements better matched that of the patch clamp.
"That's the idea of everything we want to put together: large-scale voltage imaging of genetically tagged neurons in freely behaving animals," Wilson said.
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