The study reveals that the most common anti-fungals prompt pathogens to undergo self-destructive processes.
In groundbreaking research led by the University of Exeter, scientists have found that the world’s most commonly used antifungals prompt pathogens to destroy themselves.In a study, led by Professor Gero Steinberg investigated what happens in the case of the fungus Zymoseptoria tritici.
They used live-cell imaging and molecular genetics approaches, the goal was to understand why inhibiting ergosterol synthesis results in fungal cell death. This triggers a process called apoptosis, or the so-called “suicide” program. Ultimately causing the cell to consume itself, leading to macroautophagy.Lead author Gero Steinberg stated that their findings rewrite the common understanding of how azoles kill fungal pathogens.
The same mechanism was discovered in the rice fungus Magnaporthe oryzae. This fungus causes a disease that destroys about 30 percent of rice. They also tested some antifungal drugs, and all led to the same response.
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