The psychedelic drug causes some lasting changes to the communication pathways that connect distinct brain regions. The psychedelic drug causes some lasting changes to the communication pathways that connect distinct brain regions.
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser . In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.This heat map shows how patterns of resting brain activity change when psilocybin is taken , then return to normal as the drug wears off.
Most of these changes lasted for a few hours, but one key link between different parts of the brain remained disrupted for weeks.Psilocybin is one of several psychedelic drugs, including LSD, ketamine and MDMA , that are being investigated as therapies for conditions such as depression and post-traumatic stress disorder.
The researchers also found that a mental exercise called ‘grounding’, which is commonly used in psychedelic therapy to dampen the unpleasant effects of a drug by diverting the recipient’s attention to their surroundings, diminished psilocybin’s effects on the brain. This suggests there could be a neurological signal that grounding techniques can influence, Siegel says.
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