Zepbound outperforms Ozempic and Wegovy in head-to-head weight loss study

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Zepbound outperforms Ozempic and Wegovy in head-to-head weight loss study
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The World Health Organization issued an alert on falsified versions of Ozempic, the popular drug used to treat type 2 diabetes and obesity. The WHO warned health care professionals and the public to be aware of the counterfeits, which it said are increasing as demand for the drugs grows. NBC News' Anne Thompson reports.

Tirzepatide, the active ingredient in Eli Lilly’s Mounjaro and Zepbound, leads to more weight loss than semaglutide, the active ingredient in Novo Nordisk’s Ozempic and Wegovy, new research suggests. The study, published Monday in JAMA Internal Medicine, is thought to be the first head-to-head comparison of the two blockbuster weight loss drugs. Since Zepbound was approved for weight loss in late 2023, it appeared to have an advantage over Wegovy.

Researchers will still need to do a randomized, controlled clinical trial to see which medication truly comes out on top. Last year, Lilly began a phase 3 trial of 700 patients comparing the two medications. The trial is expected to be completed in November, according to ClinicalTrials.gov.

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