New research links dozens more genes with stroke, identifies potential drug targets nature
We thank the participants and staff of contributing studies. We also thank Michèle M. Sale, who passed away in 2018, for her important contributions to some of the studies included in this manuscript, as principal investigator of one of the grants that funded “The Sea Islands Genetics Network ” .
. She contributed specifically to SIGNET-REGARDS from the REasons for Geographic And Racial Differences in Stroke and served as a key contributor to SiGN, COMPASS and METASTROKE.These authors contributed equally: Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C. Posner These authors jointly supervised this work: Christian T. Ruff, Mayowa O. Owolabi, Jennifer E. Huffman, Lili Milani, Yoichiro Kamatani, Martin Dichgans, Stephanie DebetteBordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France Aniket Mishra, Quentin Le Grand, Ilana Caro, Constance Bordes, David-Alexandre Trégouët, Marine Germain, Christophe Tzourio, Jean-François Dartigues, Sara Kaffashian, Quentin Le Grand, Florence Saillour-Glenisson & Stephanie DebetteRainer Malik, Marios K. Georgakis, Steffen Tiedt & Martin DichgansTsuyoshi Hachiya, Makoto Sasaki, Atsushi Shimizu, Yoichi Sutoh, Kozo Tanno & Kenji SobueTuuli Jürgenson, Kristi Krebs, Kaido Lepik, Tõnu Esko, Andres Metspalu, Reedik Mägi, Mari Nelis & Lili MilaniDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, JapanMassachusetts Veterans Epidemiology Research and Information Center , VA Boston Healthcare System, Boston, MA, USAFrederick K. Kamanu, Nicholas A. Marston, Marc S. Sabatine & Christian T. Ruff Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USADivision of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, JapanLaboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, JapanCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA Marios K. Georgakis, Livia Parodi, Jonathan Rosand, Christopher D. Anderson, Ernst Mayerhofer & Christopher D. Anderson Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA Marios K. Georgakis, Livia Parodi, Phil L. de Jager, Jonathan Rosand, Christopher D. Anderson, Guido J. Falcone, Phil L. de Jager, Ernst Mayerhofer & Christopher D. Anderson Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, JapanDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, TaiwanDepartment of Internal Medicine, University of Turku, Turku, FinlandDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Turku, FinlandNuffield Department of Population Health, University of Oxford, Oxford, UK Kuang Lin, Zhengming Chen, Cornelia M. van Duijn, Robert Clarke, Rory Collins, Richard Peto, Yiping Chen, Zammy Fairhurst-Hunter, Michael Hill, Alfred Pozarickij, Dan Schmidt, Becky Stevens, Iain Turnbull, Iona Y. Millwood, Keum Ji Jung & Robin G. Walters Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway Bendik Slagsvold Winsvold, Ingrid Heuch, Linda M. Pedersen, Amy E. Martinsen, Espen S. Kristoffersen & John-Anker Zwart K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , Trondheim, Norway Bendik Slagsvold Winsvold, Sigrid Børte, Kristian Hveem, Ben M. Brumpton, Jonas B. Nielsen, Maiken E. Gabrielsen, Anne H. Skogholt, Ben M. Brumpton, Maiken E. Gabrielsen, Amy E. Martinsen, Jonas B. Nielsen, Kristian Hveem, Laurent F. Thomas & John-Anker ZwartBendik Slagsvold Winsvold & Anne H. Aamodt Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Neurology and Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of KoreaGanesh Chauhan, Amit Kumar & Kameshwar Prasad Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, CanadaDepartment of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, CanadaDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland Liisa Tomppo, Jukka Putaala, Gerli Sibolt, Nicolas Martinez-Majander, Sami Curtze, Marjaana Tiainen, Janne Kinnunen & Daniel Strbian Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, NigeriaNeuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, NigeriaDepartment of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands Gennady V. Roshchupkin, Maria J. Knol, Cornelia M. van Duijn, Najaf Amin, Sven J. van der Lee, Mohsen Ghanbari, Mohammad K. Ikram & Mohammad A. Ikram Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The NetherlandsThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, IsraelDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USADepartment of Clinical Biochemistry, Copenhagen University Hospital—Rigshospitalet, Copenhagen, DenmarkDepartment of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA, USADepartment of Public Health Sciences, College of Medicine, The Pennsylvania State University, State College, PA, USAStroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau , Barcelona, Spain Jara Cárcel-Márquez, Nuria P. Torres-Aguila, Natalia Cullell, Elena Muiño, Cristina Gallego-Fabrega, Miquel Lledós, Laia Llucià-Carol & Israel Fernández-CadenasThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Genetics, Odense University Hospital, Odense, DenmarkCenter for Alzheimer’s and Related Dementias, National Institutes of Health, Bethesda, MD, USALaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USAHampton L. Leonard & Mike A. NallsChaojie Yang, Ani Manichaikul, Stephen S. Rich, Wei Min Chen, Michèle M. Sale & Wei-Min ChenChaojie Yang British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UKDepartment of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UKDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Surgery, University of Pennsylvania, Philadelphia, PA, USADepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanUniversity of Lille, INSERM U1167, RID-AGE, LabEx DISTALZ, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceInstitut Pasteur de Lille, Lille, FranceDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USAUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, University Utrecht, Utrecht, The NetherlandsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USADepartment of Biostatistics, University of Washington, Seattle, WA, USA Traci M. Bartz, Natalie C. Gasca, Barbara McKnight, Kenneth Rice, Cathy C. Laurie, Quenna Wong & Natalie C. GascaInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayResearch and Communication Unit for Musculoskeletal Health , Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, NorwayPaul M. Ridker, Franco Giulianini, Julie E. Buring & Daniel I. ChasmanMRC Population Health Research Unit, University of Oxford, Oxford, UKDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USANeuroGenomics and Informatics Center, Washington University School of Medicine, Saint Louis, MO, USAJohn W. ColeJohn W. Cole & Steven J. Kittner Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USAGenomesForLife—GCAT Lab Group, Germans Trias i Pujol Research Institute , Badalona, SpainKlinik und Hochschulambulanz für Neurologie, Charité—Universitätsmedizin Berlin, Berlin, GermanyGerman Center for Neurodegenerative Diseases , partner site Berlin, Berlin, GermanyMatthias Endres Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, BrazilDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands Mirjam I. Geerlings, N. Charlotte Onland-Moret, Paul I. W. de Bakker, Mirjam I. Geerlings, Jet M. J. Vonk, N. Charlotte Onland-Moret, Ina L. Rissanen & Thomas LimanVilmundur Gudnason, Vilmundur Gudnason & Sigurdur SigurdssonVilmundur Gudnason, Kari Stefansson & Vilmundur Gudnason Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UKDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FinlandInstitute for Molecular Medicine Finland, FIMM-HiLIFE, Helsinki, FinlandClinical Trial Service and Epidemiological Studies Unit , Nuffield Department of Population Health, University of Oxford, Oxford, UKDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USACambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UKCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, AustraliaHealth Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UKBritish Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UKDepartment of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The NetherlandsLos Angeles County Department of Public Health, Los Angeles, CA, USAInstitute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Biology, Brody School of Medicine Center for Health Disparities, East Carolina University, Greenville, NC, USADepartment of Neurology and Geriatric Research and Education Clinical Center, VA Maryland Health Care System, Baltimore, MD, USADepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, AustraliaIntramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USAKeon-Joo LeeSwiss Institute of Bioinformatics, Lausanne, SwitzerlandKaido Lepik Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, ChinaStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UKInstitute of Human Genetics, Technical University of Munich, Munich, GermanyInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USAGeriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USAInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, GermanyDepartment of Neurology, University Hospital Würzburg, Würzburg, GermanyThe MIND Center, University of Mississippi Medical Center, Jackson, MS, USADepartment of Clinical Biochemistry, Copenhagen University Hospital—Herlev and Gentofte, Copenhagen, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Børge G. Nordestgaard, Anne Tybjærg-Hansen, Børge G. Nordestgaard, Marianne Benn, Shoaib Afzal & Ruth Frikke-SchmidtDepartment of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanLaboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, JapanLaboratory of Statistical Immunology, Immunology Frontier Research Center , Osaka University, Suita, JapanIntegrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, JapanCenter for Infectious Disease Education and Research , Osaka University, Suita, JapanWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USAInstitute of Epidemiology, Helmholtz Zentrum München,, German Research Center for Environmental Health, Neuherberg, GermanyInstitute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilian University Munich, Munich, GermanyAnnette Peters & Martina Müller-NurasyidBruce M. Psaty, Nicholas L. Smith, Alexander Reiner, Sara Lindstrom, William Gordon, Susan R. Heckbert, Alexander P. Reiner & W. T. LongstrethBruce M. PsatyJonathan Rosand, Christopher D. Anderson & Christopher D. AndersonRalph L. Sacco & Tatjana RundekDivision of Cardiology, Department of Medicine, Columbia University, New York, NY, USAElse Charlotte SandsetElse Charlotte Sandset Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA Muralidharan Sargurupremraj, Claudia L. Satizabal, Xueqiu Jian, Antti-Pekka Sarin, Bernard Fongang, Muralidharan Sargurupremraj & Sudha SeshadriClaudia L. Satizabal, Qiong Yang, Ming-Huei Chen, Marja K. Puurunen, Chris J. O’Donnell, Andrew D. Johnson, Xueqiu Jian, Vasileios Lioutas, Anita L. DeStefano, Hugo J. Aparicio, Alexa S. Beiser, Ayesha Chowhan, Jose R. Romero, Alexa S. Beiser, Bernard Fongang, Ruiqi Wang & Sudha SeshadriCarsten O. Schmidt, Alexander Teumer & Henry Völzke Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USADepartment of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USAKelly L. SloaneDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USADepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Unviersity Hospital, Gothenburg, SwedenDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsStella Trompet & J. Wouter Jukema Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsDepartment of Neurology and Neurosurgery, University of Tartu, Tartu, EstoniaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USADepartment of Public Health and Clinical Medicine, Umeå University, Umeå, SwedenDepartment of Medicine, Division of Cardiovascular Disease, Emory University School of Medicine, Atlanta, GA, USADepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USADivision of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of KoreaResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, GermanyGerman Center for Neurodegenerative Diseases , site Rostock/Greifswald, Rostock, GermanyEinthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The NetherlandsDepartment of Clinical Genetics, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The NetherlandsDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USADepartment of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, DenmarkDepartment of Neurology, University of Virginia, Charlottesville, VA, USADepartment of Public Health Science, University of Virginia, Charlottesville, VA, USALongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USARamin Zand Department of Neurology, College of Medicine, The Pennsylvania State University, State College, PA, USAThomas LimanPeter Ulrich HeuschmannDepartment of Neurology, University of Washington, Seattle, WA, USAInstitute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of KoreaDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, CanadaPopulation Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, CanadaDepartment of Surgery and Department of Genetics, University of Pennsylvania, Philadelphia, PA, USAScott M. Damrauer The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USADepartment of Neurology, Brigham and Women’s Hospital, Boston, MA, USADivision of Medicine, Turku University Hospital, Turku, FinlandBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USAHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USADepartment of Medical Imaging, Chung Shan Medical University Hospital, Taichung, TaiwanHugo J. Aparicio, Ayesha Chowhan, Jose R. Romero & Sudha SeshadriAbiodun M. Adeoye, Adekunle G. Fakunle, Ezinne Uvere, Abimbola Olalere, Olayinka J. Adebajo & Mayowa O. OwolabiGerman Center for Neurodegenerative Diseases , Munich, GermanyDepartment of Neurology, Institute for Neurodegenerative Diseases, CHU de Bordeaux, Bordeaux, FranceDepartment of Neurology, Washington University School of Medicine, Saint Louis, MO, USABaltimore Veterans Administration Medical Center and University of Maryland School of Medicine, Baltimore, MD, USALaboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USAUniversity of Mississippi Medical Center, Jackson, MS, USAWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKSocial, Genetic and Developmental Psychiatry Centre, King’s College London, London, UKInitiative for Research and Education to Advance Community Health, Washington State University, Seattle, WA, USADivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Alexander Reiner, Jeffrey Haessler, Charles Kooperberg, Charles Kooperberg, Sara Lindstrom, Jeffrey Haessler, Alexander P. Reiner & Barbara McKnightCarl D. Langefeld & Yong Mei LiuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USAStroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USAUniversity of California, San Francisco, San Francisco, CA, USABrown University Warren Alpert Medical School, Providence, RI, USADonna K. ArnettNeuroscience Institute, Saint Francis Medical Center, Trenton, NJ, USAHUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , Trondheim, NorwayDepartment of Research, Innovation and Education, St Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USADepartment of Pediatrics and Rady Children’s Hospital, University of California San Diego, La Jolla, CA, USAK. G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT—The Arctic University of Norway, Tromsø, NorwayDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The NetherlandsDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USADivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USABen M. Brumpton Clinic of Thoracic and Occupational Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayPierre Suchon, Manal Ibrahim & Pierre-Emmanuel MorangePierre Suchon & Pierre-Emmanuel MorangeKelly A. Frazer Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health, Boston, MA, USADivision of Internal Medicine, University Hospital of North Norway, Tromsø, NorwayDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USADivision of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, USADepartment of Internal Medicine and the Center for Clinical and Translational Science, Ohio State University, Columbus, OH, USADepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USADepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor–UCLA Medical Center, Torrance, CA, USADivision of Genomic Outcomes, Department of Pediatrics, Harbor–UCLA Medical Center, Torrance, CA, USADivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USACentre National de Recherche en Génomique Humaine, Direction de la Recherche Fondamentale, CEA, Evry, FranceMillion Veteran’s Program, Veteran’s Administration, Boston, MA, USAPierre-Emmanuel Morange Center for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USAChristopher KabrhelPeter J. Koudstaal & Mohammad K. IkramGert-Jan LuijckxPaul J. Nederkoorn, Marieke C. Visser & Paul J. Nederkoorn Department of Neurology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, The NetherlandsJohn Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, AustraliaFaculty of Health, University of Technology Sydney, Ultimo, New South Wales, AustraliaDepartment of Neurology, IMIM-Hospital del Mar, Neurovascular Research Group, IMIM , Universitat Autònoma de Barcelona/DCEXS-Universitat Pompeu Fabra, Barcelona, SpainInstitute of Cardiovascular Research, Royal Holloway University of London, London, UKPankaj Sharma & Ioana Cotlarciuc Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UKDepartment of Neurology, Medical University of Graz, Graz, AustriaAgnieszka Slowik & Joanna Pera Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Melbourne, Victoria, AustraliaVincent N. S. ThijsArne G. Lindgren, Andreea Ilinca, Hossein Delavaran & Bo Norrving Department of Neurology, Rehabilitation Medicine, Memory Disorders, Geriatrics, Skåne University Hospital, Lund, SwedenDepartment of Clinical Sciences, Lund University, Malmö, SwedenDepartment of Medicine, Brigham and Women’s Hospital, Boston, MA, USAWolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USADivision of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL, USABHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UKNIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UKBritish Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UKNational Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UKDepartment of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO, USADepartment of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Milan, ItalyLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, JapanDepartment of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, ItalyArndt RolfsAnne-Katrin Giese, Anne-Katrin Giese & Natalia S. RostDepartment of Neurosciences, Experimental Neurology, KU Leuven–University of Leuven, Leuven, BelgiumDepartment of Neurology, VIB Center for Brain & Disease Research, University Hospitals Leuven, Leuven, BelgiumDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USADepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, SwedenRegion Västra Götaland, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, SwedenTsong-Hai LeeOscar L. LopezStroke Pharmacogenomics and Genetics Laboratory, Fundación Docència I Recerca Mútua Terrassa, Hospital Mútua Terrassa, Terrassa, SpainNeurovascular Research Laboratory, Vall d’Hebron Institute of Research, Universitat Autònoma de Barcelona, Barcelona, SpainNeurology Service, Hospital Universitari Mútua Terrassa, Terrassa, SpainVasileios Lioutas Institute de Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC/University of Seville and Department of Neurology, Hospital Universitario Virgen Macarena, Seville, SpainDepartment of Epidemiology, Human Genetics, and Environmental Sciences , UTHealth Science Center, School of Public Health, Houston, TX, USABHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, Glasgow, UKGerman Centre for Cardiovascular Research , partner site Greifswald, Greifswald, GermanyProgram in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USADepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, JapanSolveig Gretarsdottir, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Mamoru Satoh, Ásgeir Sigurdsson & Kari StefanssonNatalia S. Rost & Hakan AyAA Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, Boston, MA, USADepartment of Neurology, Mayo Clinic, Rochester, MN, USAStroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, SpainDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, The NetherlandsAnita L. DeStefano The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Uppsala, SwedenQing DuanStefan T. Engelter Neurorehabilitation Unit, University of Basel and University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, Basel, SwitzerlandGuido J. Falcone Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, SwedenDepartment of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UKPublic Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales, AustraliaCollege of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, AustraliaDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USADepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USAMRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UKComputational Medicine, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, GermanyClaudia LangenbergMRC Biostatistics Unit, University of Cambridge, Cambridge, UKErik LorentzenPatrik K. Magnusson & Nancy L. Pedersen Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, JapanDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USADepartment of Neurology, Justus Liebig University, Giessen, GermanyChristophe Tzourio & Florence Saillour-GlenissonUniversity of Newcastle and Hunter Medical Research Institute, New Lambton, New South Wales, AustraliaCentre for Research in Environmental Epidemiology, Barcelona, SpainValeria CasoDepartment of Neurology, Memory Clinic, Bordeaux University Hospital, Bordeaux, FranceDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, GermanyHero DMC Heart Institute, Dayanand Medical College & Hospital, Ludhiana, IndiaAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, SwedenAtsushi Hozawa, Naoko Minegishi & Takako TakaiMartin IngelssonDepartment of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, CanadaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, JapanDepartment of Basic and Clinical Neurosciences, King’s College London, London, UKDepartments of Neurology & Radiology, Landspitali National University Hospital, Reykjavik, IcelandManja KlossDaniel L. LabovitzGenetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKCecilia M. Lindgren & Andrew P. Morris BioBankJapan, Laboratory of Clinical Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, JapanInstitute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, GermanyDepartment of Medicine I, Ludwig-Maximilians-Universität, Munich, GermanyTranslational Genomics Unit, Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, ItalyDepartment of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, SpainPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d’Hebron Research Institute , Universitat Autònoma de Barcelona,Biomedical Network Research Centre on Mental Health , Barcelona, SpainNational Institute for Health Research Comprehensive Biomedical Research Centre, Guy’s & St Thomas’ NHS Foundation Trust and King’s College London, London, UKSchool of Lifecourse and Population Sciences, King’s College London, London, UKDepartment of Epidemiology, University of Maryland School of Medicine, Baltimore, MD, USAInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UKDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, JapanDepartment of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, JapanUniversity of Caen Normandy, Caen, FranceDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USADharambir K. SangheraDepartment of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, NigeriaInstitute of Cardiovascular Diseases, University of Ibadan, Ibadan, NigeriaDepartment of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaAlbert AkpaluDepartment of Medicine, University of Ilorin Teaching Hospital, Ilorin, NigeriaDepartment of Medicine, Aminu Kano Teaching Hospital, Kano, NigeriaDepartment of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, NigeriaDepartment of Health Promotion and Education, University of Ibadan, Ibadan, NigeriaDepartment of Radiology, College of Medicine, University of Ibadan, Ibadan, NigeriaFuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing, ChinaPeking Union Medical College, Beijing, ChinaDepartment of Public Policy, Institute of Medical Sciences, The University of Tokyo, Tokyo, JapanEric Boerwinkle Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, GermanyDepartment of Neurology, Amphia Hospital, Breda, The NetherlandsDepartment of Neurology, Elisabeth-Tweesteden Hospital, Tilburg, The NetherlandsSarah E. VermeerDepartment of Neurology, Catharina Hospital, Eindhoven, The NetherlandsTom den HeijerDepartment of Neurology, Medisch Center Leeuwarden, Leeuwarden, The NetherlandsDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , Trondheim, NorwayDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USACenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USAStroke Unit, Department of Internal Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USAWei ZhouDepartment of Neurology, Akershus University Hospital, Lørenskog, NorwayBioCore—Bioinformatics Core Facility, Norwegian University of Science and Technology , Trondheim, NorwayClinic of Laboratory Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology , Trondheim, NorwayDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences , University Hospital Essen, University Duisburg-Essen, Essen, GermanyStefan Frantz Stroke Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Cristina Gallego-Fabrega, Raquel Delgado-Mederos, Luis Prats-Sánchez, Pol Camps-Renom & Joan Martí-Fàbregas Institute for Biomedical Research of Barcelona , National Spanish Research Council , Barcelona, SpainClinical Neurosciences Research Laboratory , Health Research Institute of Santiago de Compostela , Santiago de Compostela, SpainDepartment of Neurology, Biocruces-Bizkaia Health Research Institute, Bilbao, SpainStroke Unit, Department of Neurology, University Hospital of Valladolid, Valladolid, SpainDepartment of Neurology, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, SpainStroke Unit, Department of Neurology, Hospital Universitari Vall d’Hebron, Barcelona, SpainDepartment of Neurosciences, Hospital Germans Trias I Pujol, Universitat Autònoma de Barcelona, Barcelona, SpainDepartment of Neurology, University Hospital Central de Asturias , Oviedo, SpainDepartment of Neurology, Son Espases University Hospital, Illes Balears Health Research Institute , Palma, SpainDepartment of Neurology, University Hospital of Albacete, Albacete, SpainHigh Content Genomics and Bioinformatics Unit, Germans Trias i Pujol Research Institute , Badalona, SpainThe Copenhagen City Heart Study, Copenhagen University Hospital—Bispebjerg and Frederiksberg, Copenhagen, DenmarkCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USAThe Centre for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA
Please follow us on Google to support us United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson’s disease genesAbstract. Genome-wide association studies (GWAS) have markedly advanced our understanding of the genetics of Parkinson’s disease (PD), but they currently do not
Read more »
What Donald Trump understandsA new book details Donald Trump’s grim view of human nature, and how he exploited it shrewdly—to a point
Read more »
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups - Nature GeneticsCross-disorder genetic association analyses identify five loci differentiating attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Individuals diagnosed with both ADHD and ASD are double-loaded with genetic risk for both disorders.
Read more »
Kate Garraway recently discovered she has a VERY famous relativeKate Garraway made the discovery while taking part in ITV's DNA Journey.
Read more »