Researchers found that post-COVID-19 condition (PCC) symptoms persist in a significant number of both SARS-CoV-2 positive and negative emergency department patients, highlighting the non-specific nature of the WHO’s PCC criteria.
By Vijay Kumar MalesuReviewed by Susha Cheriyedath, M.Sc.Oct 1 2024 In a recent study published in the journal Nature Communications, a group of researchers compared the proportion of emergency department patients who developed Post- Coronavirus disease 2019 Condition symptoms between those who tested positive and those who tested negative for Severe Acute Respiratory Syndrome Coronavirus 2 infection.
About the study The Canadian COVID-19 Emergency Department Rapid Response Network conducted a PCC sub-study across 33 sites in five provinces. Ethical approval was granted with a waiver of informed consent, and participants provided verbal consent for follow-up phone interviews. Adults tested for SARS-CoV-2 in emergency departments between October 2020 and February 2022 were eligible, with exclusions for those deceased, hospitalized, unreachable, or unable to communicate.
Research assistants collected data through chart reviews and phone follow-ups, documenting demographic, clinical, and vaccination information. The primary outcome was the proportion of patients reporting PCC-consistent symptoms at three months, with secondary outcomes assessing specific symptoms at six and twelve months. Statistical analyses, including logistic regression, were performed to evaluate associations between SARS-CoV-2 status and PCC symptoms, adjusting for key covariates.
Test-positive patients reported PCC symptoms at twice the rate of test-negative patients, particularly for anosmia, dysgeusia , and persistent cough. Patients infected during the Omicron period reported more memory, concentration, and dizziness issues than those infected pre-Omicron. The strongest predictor of PCC at three months was testing positive for SARS-CoV-2 during the index visit .
Anosmia Coronavirus Cough Dexamethasone Diagnostic Dysgeusia Education Fatigue Omicron Pandemic Research Respiratory SARS SARS-Cov-2 Severe Acute Respiratory Severe Acute Respiratory Syndrome Syndrome
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