A study conducted by researchers at Weill Cornell Medicine has found that women are at a higher risk of death during heart bypass surgery compared to men. The study suggests that this disparity is largely due to intraoperative anemia, the loss of red blood cells during surgery. Strategies for minimizing anemia during the procedure could potentially improve outcomes for women with cardiovascular disease.
Apr 13 2024 Weill Cornell Medicine Women are at higher risk of death when undergoing heart bypass surgery than men. Researchers at Weill Cornell Medicine have determined that this disparity is mediated, to a large extent, by intraoperative anemia-;the loss of red blood cells during surgery.
This study set out to discover why women are less likely to survive coronary artery bypass grafting, a surgical procedure for restoring blood flow to the heart. The team, led by senior author Dr. Mario Gaudino, the Stephen and Suzanne Weiss Professor in Cardiothoracic Surgery at Weill Cornell Medicine, analyzed information obtained from the Society of Thoracic Surgeons Adult Cardiac Surgery Database on more than one million patients. Dr.
The study does not establish that intraoperative anemia is causing greater female mortality, but the two factors are associated. It suggests that clinicians and researchers should consider interventions to prevent or minimize severe intraoperative anemia, which can lead to dangerously reduced oxygen delivery to the body's tissues, including the heart.
Related StoriesUsing heart-lung bypass machines with shorter circuits, for example, would limit the volume of blood-diluting solution needed to run the pump. Randomized trials to assess whether methods for curtailing anemia could improve outcomes for women undergoing heart bypass surgery are "urgently needed," wrote Dr. Gaudino, who is also a cardiovascular surgeon at NewYork-Presbyterian/Weill Cornell Medical Center.
This research was supported in part by the National Heart, Lung, and Blood Institute grant T32 HL160520-01A1, the National Institutes of Health, the Canadian Health and Research Institutes, and the Starr Foundation.Journal reference:Harik, L., et al. . Intraoperative Anemia Mediates Sex Disparity in Operative Mortality After Coronary Artery Bypass Grafting. Journal of the American College of Cardiology. doi.org/10.1016/j.jacc.2023.12.032.
Women Heart Bypass Surgery Death Risk Weill Cornell Medicine Intraoperative Anemia Cardiovascular Disease
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