A randomized trial of a blood thinner after severe COVID-19 to prevent clotting events Blood Coronavirus Disease COVID Hematology Thromboprophylaxis annalsofim
They assessed the efficacy of extended thromboprophylaxis in controlling thromboembolic complications among patients discharged from coronavirus disease 2019 hospitalization.
Depending on the illness severity, doctors give anticoagulant therapy to such patients to prevent thromboembolic complications during the hospital stay. More specifically, this double-blind, placebo-controlled trial included 18 years or older participants hospitalized for COVID-19 for two or more days and ready for discharge. The team compared the efficacy and safety of clinically available antithrombotic strategies in these patients.
Related StoriesIn stage one of this protocol, the researchers randomly assigned study participants to apixaban, an anticoagulant therapy, and placebo groups, with individuals in the former group receiving two doses of 2.5 mg of apixaban daily, the latter a matching placebo. The primary endpoint of this study encompassed all-cause mortality and venous and arterial thromboembolic events; examples include pulmonary embolism and myocardial infarction within 30 days. The secondary endpoints covered all the primary endpoints at days 45 and 90 of follow-up.
In the placebo-treated participants, the study estimated primary endpoint rate was 4% by day 30 after hospital discharge. The composite primary outcome rates were even lower, i.e., 2.3%, suggesting that the increased risk for thromboembolic events during hospitalization was not so distinct post-discharge.
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