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Researchers discovered that lower folate intake may enhance metabolic health and promote healthier aging in animal models, challenging the established belief that high folate consumption is universally beneficial. The study suggests that optimal folate levels might vary with age, advocating for tailored dietary guidelines.In a study published indiscovered that reducing folate intake can promote healthier metabolisms in aging animal models.
Folate, a B vitamin essential for cell growth and development, is widely recognized for its role in preventing birth defects. It’s found naturally in foods like leafy greens, and it is typically added to refined grains. Despite its prevalence, the long-term health implications of consuming high amounts of folate throughout life are unclear.
The study supports the concept of precision nutrition, advocating for personalized dietary recommendations. This is a research pillar of the Texas A&M AgriLife Institute for Advancing Health through Agriculture, IHA, where Polymenis is an affiliate member. The researchers found the female folate-limited models were able to transition quicker between carbohydrate metabolism and fat metabolism across night and day compared to females on a typical diet.
Blank said the folate-limited group maintained their weight and body fat into old age as opposed to the control group. And despite folate’s importance for red blood cell production, the folate-limited models showed no signs of anemia or other negative health consequences. Looking forward, the team’s next step will be to repeat the experiment in more genetically diverse models, simulating the genetic diversity of humans.
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