Anticoronavirals: the development of COVID-19 therapies and the challenges that remain NatureMicrobiol pfizer COVID19 coronavirus covid antivirals therapies
By Neha MathurMay 8 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in Nature Microbiology, researchers highlighted the pace of development of coronavirus disease 2019 therapies during the pandemic and the challenges that hinder the widespread availability of anticoronavirals.
Clinical trials have established that mAbs and antivirals effectively combat COVID-19 when administered up to 10 days after symptom onset and within three to five days following the onset of symptoms, respectively. COVID-19 patients in stage 2 develop viral pneumonia, cough and fever, lung inflammation causing shortness of breath, and lung aberrations, such as ground glass opacities.
The NIH rejected giving vitamin/mineral supplements, e.g., zinc, for hospitalized COVID-19 patients. On the contrary, they recommended prompt use of supplemental oxygenation and high-flow nasal cannula in patients with ARDS. In the absence of effective treatments, clinical recommendations by NIH continue to change and evolve.
Another randomized phase III trial evaluated ivermectin, metformin, and fluvoxamine, all repurposed drug candidates, for early COVID-19 treatment of overweight or obese adults. Earlier pivotal efficacy and clinical studies found that molnupiravir provided no clinical benefit in hospitalized COVID-19 patients.
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