The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities.
University of GöttingenJun 24 2024 A research team from the University of Göttingen has now discovered an important function of antisense RNA : the researchers found that as RNA acts as a "superhighway" in cell transport and thus accelerates gene expression . The results were published in Nature.
RNA plays a central role in the translation of DNA information into proteins. There are different types of RNA, one of which is known as messenger RNA . Messenger RNA is a type of coding RNA and its job is to transmit the building instructions for proteins from the DNA in the cell nucleus out into the cytoplasm, where other cell components translate them into proteins. In addition to coding RNA, there are large quantities of non-coding RNA.
It seemed unbelievable to me that a cell would produce RNAs without a purpose. This is contrary to nature." Krebber's team discovered that asRNA combines with mRNA, which is then preferentially transported from the cell nucleus into the cytoplasm. This means that the cell translates the information from the mRNA into proteins faster than would be the case without asRNA. Therefore, asRNA serves as a "booster" for gene expression.
The new research findings about asRNAs solve the long-standing question of why the cell sometimes produces large quantities of asRNA. "In biology, this is particularly striking because the cell expends a lot of energy on asRNA production," explains Krebber.
Gene Expression Antisense Cell Cell Nucleus Cytoplasm DNA Genetics Microbiology Quality Control Research Ribonucleic Acid RNA Stress Translation
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