Approved and developing passive and active immunizations against respiratory syncytial virus in childhood and pregnancy PUCRS vaccine vaccination virus virology disease respiratory
By Bhavana KunkalikarNov 22 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Jornal de Pediatria, researchers explored active and passive vaccination among children against respiratory syncytial virus .
The growing understanding of the immune response to RSV and the growing recognition of the RSV disease burden has resulted in considerable growth in the number of worthy candidates for passive and active vaccination. A combination of techniques, such as passive and active immunization, is the optimal strategy for primarily protecting newborns and preschoolers.
Notably, in one of the analyses comprising seven phases, one trial performed on 239 infants aged between six and 24 months evaluated five vaccines under development that elicited neutralizing antibody responses among 80% of vaccinated subjects. The efficiency in lowering RSV episodes of acute respiratory illness that needed medical treatment was 67%, with an 88% reduction in RSV-related lower respiratory tract infections .
mRNA vaccines A phase 1 investigation of the mRNA-1345 vaccine encoding stabilized pre-F RSV is now ongoing in healthy women of reproductive age, RSV-seropositive children between 12 and 59 months, and the elderly. As an added benefit, mRNA vaccinations against RSV can be paired with mRNA vaccines, which are also being investigated in adults against influenza and SARS-CoV-2.
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