One of the lead scientists behind the University of Queensland’s molecular clamp vaccine technology says it could be as good or better than mRNA vaccines, as it heads into phase I clinical trials.
The vaccine platform uses a small molecule to “clamp” a protein into the same shape as the protein on the surface of a virus, triggering the same immune response from the body.The first version of the clamp was considered a frontrunner to produce a viable vaccine for COVID-19,There was no risk of HIV infection to people who had the vaccine, but the potential impact on national screening programs was too great., version 2.
“Firstly, safety – in our first clinical trial [for version 1.0] we didn’t see any incidences of headaches or fevers or those sorts of responses associated with mRNA vaccines. Clamp 2.0 will be put through its paces against the TGA-approved Novovax vaccine, which is not an mRNA vaccine, but which Chappell said would provide a good comparison.“We are recruiting 70 individuals for the trial – half will receive our vaccine and the other half will get the Novovax,” he said.“We’re excited about that, it’s putting the Brisbane, Australian-based technology up against one of the best COVID-19 vaccines.
UQ’s clamp technology has been supported from an early stage by the Coalition for Epidemic Preparedness Innovation , which provided $8.5 million for the current round of development.The clinical trial will be run by Nucleus Network, with the company’s chief medical officer Jason Lickliter saying they were also excited by the vaccine’s potential.
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