Learn how to assess peptide stability characterization under both stir and thermal stress.
Sponsored Content by Yokogawa Fluence AnalyticsReviewed by Olivia FrostOct 15 2024 ARGEN, by Fluence Analytics, offers scientists the instruments they need to effortlessly surveil changes in the normalized molecular weight of peptide samples in solution. It facilitates the identification of aggregation onset, degradation, or phase changes as these phenomena occur due to thermal, stir, pH, ionic strength, and other stressors.
Method and stressors: The researchers prepared six samples of each peptide lot at 1mg/ml in two pH solutions, 2.5 and 3.0. Three of the six solutions were next exposed to thermal stress of 18C, 25C and 35C alone while the remaining samples were exposed to thermal stress and stirring stress at 300RPM.Analysis: The following graph demonstrates the quantified Aggregation Rates for all peptides with and without stirring and at various temperatures and pH levels.
Yokogawa Fluence Analytics is a global leader in real-time polymer reaction monitoring and control, and its industry-leading ACOMP product is the only commercially available smart manufacturing system that continuously monitors and measures polymerization reactions. The company’s biopharmaceutical product line includes a high-throughput static light scattering instrument called ARGEN. ARGEN can independently measure the stability of biopolymers under thermal, chemical, and mechanical stress, while also performing shelf-life stability studies at low temperatures.
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