Researchers have mapped the complex epigenetic and transcriptomic landscape of cancer, revealing key regulatory elements across 11 tumor types that could unlock new insights into cancer progression and metastasis.
By Pooja Toshniwal PahariaNov 5 2023Reviewed by Sophia Coveney In a recent study published in Nature, researchers created a pan-tumor transcriptomic and epigenetic atlas using single-nucleus chromatin accessibility information and matched ribonucleic acid -sequencing data.
About the study In the present study, researchers developed an integrated multi-omic map of 11 types of cancer based on data from more than 200 cases. Cleavage under targets and release was performed in the U251 GBM cell line utilizing a nuclease assay, profiling the direct binding of nuclear respiratory factor 1 to target gene promoters.
Results The study showed epigenetic factors linked to cancer transitions, some of which appeared in several malignancies while others were disease-specific. Cancer start was connected to epigenetically changed pathways such as TP53, hypoxia, and tumor necrosis factor signaling, whereas metastatic transition was linked to estrogen response, epithelial-mesenchymal transition, and apical junction.
In head and neck squamous cell cancer , EGFR had the largest number of enhancer-to-gene connections. There was a substantial association between enhancer accessibility and gene expression, indicating collaboration between epigenetic and genetic factors.
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