Science, Space and Technology News 2024
Antidepressants like SSRIs work by boosting neuroplasticity and connectivity in the brain, offering a fresh perspective on their role in treating depression, beyond the serotonin theory. Credit: SciTechDaily.com
New research highlights that SSRIs and other antidepressants treat depression not by correcting a serotonin imbalance, but by promoting neuroplasticity and enhancing brain region communication, reshaping clinical discussions about their effectiveness.
“The best evidence of changes in the brain in people suffering from MDD is that some brain regions are not communicating with each other normally,” says Scott Thompson, PhD, professor in the Department of Psychiatry at the University of Colorado School of Medicine and senior author. “When the parts of the brain responsible for reward, happiness, mood, self-esteem, even problem-solving in some cases, are not communicating with each other properly, then they can’t do their jobs properly.
“We are hoping this framework provides clinicians new ways to communicate the way these treatments work in combating MDD,” said C. Neill Epperson, MD, Robert Freedman endowed professor and chair of the Department of Psychiatry in the University of Colorado School of Medicine and co-author on the paper.
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