Team of sister scientists identify a possible genetic culprit for uterine corpus endometrialcancer MUSCHealth PLOSONE
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Xbox won't feature on E3 2023 show floorThe Xbox team has confirmed it won't appear on the E3 show floor for 2023, although it will feature as part of E3 Digital.
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India floats dedicated tribunal to handle internet offencesConsultation for the long-awaited Digital India Act is finally under way although the draft law's still not been revealed
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Parents should see sex education material shown to their children, says Rishi SunakConservative MPs have accused some schools of effectively encouraging teenagers to become sexually active, although these claims have been heavily contested
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Efficacy and safety of topical 0.1% cannabidiol for managing recurrent aphthous ulcers: a randomized controlled trial - BMC Complementary Medicine and TherapiesBackground Although topical steroids constitute the first-line therapy for recurrent aphthous ulcers (RAUs), their long-term use often leads to candidiasis. Although cannabidiol (CBD) can be an alternative for pharmacologically managing RAUs due to its analgesic and anti-inflammatory in vivo effects, there is a lack of clinical and safety trials concerning its use. The aim of this study was to evaluate the clinical safety and efficacy of topical 0.1% CBD for managing RAU. Methods A CBD patch test was performed on 100 healthy subjects. CBD was applied on the normal oral mucosa of 50 healthy subjects 3 times/day for 7 days. Oral examination, vital signs, and blood tests were performed pre- and post-CBD use. Another 69 RAU subjects randomly received one of three topical interventions: 0.1% CBD, 0.1% triamcinolone acetonide (TA), or placebo. These were applied on the ulcers 3 times/day for 7 days. The ulcer and erythematous size were measured on day 0, 2, 5, and 7. Pain ratings were recorded daily. The subjects rated their satisfaction with the intervention and completed a quality-of-life questionnaire (OHIP-14). Results None of the subjects exhibited allergic reactions or side effects. Their vital signs and blood parameters were stable before and after the 7-day CBD intervention. CBD and TA significantly reduced ulcer size more than placebo at all time points. The erythematous size reduction was higher in the CBD intervention than the placebo on day 2, while TA reduced the erythematous size at all time points. The pain score in the CBD group was lower compared with placebo on day 5, whereas TA reduced pain more than placebo on day 4, 5, and 7. The subjects receiving CBD reported higher satisfaction than placebo. However, the OHIP-14 scores were comparable among the interventions. Conclusions Topical 0.1% CBD reduced ulcer size and accelerated ulcer healing without side effects. CBD exerted anti-inflammatory effects in the early stage and an analgesic effect in the late
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Newcastle get first Premier League win in six as Nick Pope avoids another red cardNewcastle got their first win in six Premier League outings, although the Magpies and goalkeeper Nick Pope may have got a slice of luck in their 2-1 win over Wolves. Pope, who recently served a sus…
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Grealish and Haaland showcase Man City bromance as teammate is given hilarious 'Oscar'Jack Grealish and Erling Haaland are quickly establishing themselves as Manchester City’s newest bromance, although their teammates aren’t always feeling the benefits. The duo jokingly …
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