Science, Space and Technology News 2024
Research indicates that azoles, when combined with osteoporosis drugs known as bisphosphonates, are more effective at treating fungal infections. This combination has shown success in laboratory tests against dermatophytes, with promising implications for preventing resistance and enhancing drug efficacy.
Combining azoles with bisphosphonates enhances the treatment of fungal infections, showing significant efficacy in lab tests and potential in reducing drug resistance.These infections often develop resistance to azoles, a common anti-fungal treatment.Introduction to Fungal Infections and Current Treatments
Human skin, hair, and nails are all vulnerable to fungal infections. While these infections are usually not serious, they’re difficult to fully resolve and often recur after treatment—sometimes for years. They’re also often resistant to treatments, including a common class of antifungals called azoles.points to a new way to boost the efficacy of azoles in treating those infections—combining them with commonly available drugs called bisphosphonates, usually used to treat osteoporosis.
Carter says she was only a little surprised to see the synergistic effect in dermatophytes. This research project began years ago, she says, when her group conducted a series of genomic analyses on the response of pathogenic yeasts to drug treatment. That study led them to a genetic pathway that is “upstream” of the pathway targeted by azoles, and is instead targeted by bisphosphonates.
Aidan Kane, mycologist, lead author of the study and a Ph.D. student in Carter’s lab, used fluorescence microscopy and other methods to show that the drug combination worked by weakening the cell membrane enough that the fungus could not survive. Beyond the dermatophytes, the group also found that bisphosphonate-azole combinations could act against molds that cause invasive disease, suggesting another possible clinical application for the drugs.
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