Boosting anti-cancer antibodies by reducing their grip nature
In the study, the team examined three separate receptors , and showed there was better clustering of the receptors and signaling into the immune cells was improved when the binding was looser. For one of these, CD40, it showed better killing of tumor cells.
"Our study suggests that by changing the affinity we can effectively fine tune the antibody to the desired level and activity." Dr. Xiaojie Yu, first author of the study and now assistant professor at the School of Life Sciences at Westlake University, said,"High affinity binding has been the mantra of therapeutic antibody development for decades.
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