Brain Cell Differences Linked to Autism and Schizophrenia

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Brain Cell Differences Linked to Autism and Schizophrenia
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Research reveals distinct synaptic protein profiles in two types of layer 5 pyramidal neurons, suggesting potential links to neurodevelopmental disorders.

VIBJan 7 2025 Specific brain cells known as layer 5 pyramidal neurons play a vital role in how our brains process information. Research by the team of Prof. Joris de Wit and colleagues highlights the differences between two types of these brain cells —intratelencephalic neurons and pyramidal tract neurons—and how these differences may affect their vulnerability to conditions like autism and schizophrenia.

To understand how these brain cells exchange information through their synapses , the team of Prof. Joris de Wit used a sensitive technique called proteomics to profile the synapses of two types of mouse layer 5 neurons —intratelencephalic neurons and pyramidal tract neurons, each with different functions in relaying information.

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