Staphylococcus aureus (S. aureus) is a major cause of skin and soft tissue infections that can sometimes lead to sepsis and toxic shock syndrome.
University of California - San DiegoDec 16 2024 Staphylococcus aureus is a major cause of skin and soft tissue infections that can sometimes lead to sepsis and toxic shock syndrome . The microbe poses a significant threat to public health , made worse by the spread of methicillin-resistant Staphylococcus aureus bacteria in recent years. According to The Lancet, S. aureus was associated with more than one million deaths around the globe in 2019.
Yet, despite working well in mouse models, approximately 30 clinical trials to date have failed to result in an effective human vaccine for S. aureus. Now, UC San Diego researchers have identified a key reason for these failures, indicating that it may be possible to modify the vaccines to work in humans. In a study published on December 16, 2024 in the Journal of Clinical Investigation , they report that S.
In infancy, the majority of us are colonized with S. aureus, which hitches a ride in our nasal passages. For the most part, it doesn't harm us. But a previous study from 2022, led by Chih-Ming Tsai, Ph.D., an assistant project scientist in Liu's lab, showed that this early exposure fools our immune cells into producing modified antibodies that fail to mount an effective defense against S. aureus.
The team found that B cells -; white blood cells that make antibodies -; secrete an abundance of IL-10 when challenged with S. aureus for a second time. Within the B cells, IL-10 directs the enzymes to add a sugar called sialic acid to the Fc region of the antibodies -; the region responsible for generating an appropriate immune response.
The researchers found that like B cells, helper T cells also secrete an overabundance of IL-10 in response to S. aureus in mice previously exposed to and later vaccinated for S. aureus.
Protein Staphylococcus Aureus Antibodies Bacteria Blood Children Cytokine Efficacy Hospital Immunity Infectious Diseases Interleukin Medicine Mortality Pathogen Ph Public Health Sepsis Skin Syndrome Toxic Shock Syndrome Tsai Vaccine
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Can music therapy be the breakthrough dementia care desperately needs?Music therapy reduces distress and improves well-being in advanced dementia by meeting unmet needs, enhancing caregiver-patient understanding, and fostering humanizing connections in institutional care settings.
Read more »
Salmonella could be used to treat cancer after major research breakthroughFighting bowel cancer with Salmonella could be a step closer thanks to a new discovery by Cancer Research UK-funded teams in Glasgow and Birmingham.
Read more »
Covid could cure cancer, scientists discover – as virus ‘shrinks tumours’ in breakthrough study...Covid symptoms
Read more »
Northern reaches 'interim agreement' with union over Sunday conductors workingThe potential short-term breakthrough comes ahead of a key rail meeting on Wednesday
Read more »
Scientific breakthrough gives new hope to building quantum computersResearch from Google on ‘error correction’ could help create a working full-scale system this decade
Read more »
Astronomers track asteroids heading for Earth in major breakthrough“For most astronomers, asteroids are sort of seen as the vermin of the sky, in the sense that they just cross your field of view and affect your data'
Read more »