The Horner–Wadsworth–Emmons (HWE) reaction is a fundamental reaction in organic chemistry, widely used to create conjugated carbonyl compounds.
Tokyo University of ScienceDec 6 2024 The Horner–Wadsworth–Emmons reaction is a fundamental reaction in organic chemistry , widely used to create conjugated carbonyl compounds. Conjugated carbonyl compounds are used in many industries for synthesizing perfumes, plastics, and pharmaceuticals and are also involved in biological processes. Consequently, methods for improving HWE reactions are an active area of research.
In a breakthrough, a research team from the Department of Applied Chemistry at Tokyo University of Science , Japan, led by Assistant Professor Takatsugu Murata, including Mr. Hisazumi Tsutsui and Professor Isamu Shiina from TUS, conducted a detailed study on HWE reactions and developed a robust and highly -selective Weinreb amide-type HWE reaction with a broad substrate scope.
Interestingly, the researchers also found that the magnesium phosphonoenolate intermediate formed using the iPrMgCl base was stable enough to be isolated. This isolated intermediate was exceptionally stable, showing no deterioration when stored at room temperature in an argon atmosphere for over six months. This intermediate could be directly used in HWE reaction with high -selectivity.
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