Researchers from Auburn University, partnering with the University of Basel in Switzerland, have discovered a new way to make a cancer-targeting protein complex more stable, opening doors to better cancer treatments.
Auburn UniversityNov 15 2024 Led by Dr. Rafael Bernardi from Auburn's Department of Physics and Dr. Michael Nash from the Department of Chemistry at the University of Basel, the study focuses on PD-L1 , a protein that tumors use to hide from the immune system. In many cancers, PD-L1 acts as a "shield," binding to immune cells and signaling them to ignore the cancer, allowing the tumor to grow undetected.
Published in ACS Nano, a leading scientific journal from the American Chemical Society, the study introduces the concept of "force anisotropy," demonstrating how the strength of the PD-L1 and Affibody pairing varies based on specific attachment points. The team discovered that adjusting the attachment points on PD-L1 could make this pair up to four times stronger.
This discovery could lead to more reliable drug delivery systems, allowing researchers to develop cancer therapies that target tumors more precisely and stay effective longer. Dr. Bernardi's team is now looking to design even stronger Affibody proteins that can find and attach to different cancer types with greater accuracy.
Protein Drug Delivery Drugs Immune System PD-L1 Research Tumor
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