Dana-Farber Cancer Institute researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma (a form of kidney cancer), generated a successful anti-cancer immune response after initiation of a personalized cancer vaccine.
Dana-Farber Cancer InstituteFeb 5 2025 Dana-Farber Cancer Institute researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma , generated a successful anti-cancer immune response after initiation of a personalized cancer vaccine. The vaccines were administered after surgery to remove the tumor and are designed to train the body's immune system to recognize and eliminate any remaining tumor cells.
Patrick Ott, MD, PhD, director of the Center for Cancer Vaccines at Dana-Farber, and Derin Keskin, PhD, immunologist at the Center for Cancer Vaccines at Dana-Farber, are also co-senior authors. David A. Braun, MD, PhD, formerly of Dana-Farber and Harvard Medical School, and now a medical oncologist and physician-scientist at Yale Cancer Center and Yale School of Medicine is first author.
In this investigator-initiated trial, Choueiri and Braun treated nine patients with stage III or IV clear cell renal cell carcinoma with a personalized cancer vaccine after surgery. Five patients also received ipilimumab with the vaccine. "This approach is truly distinct from vaccine attempts in kidney cancer" says Braun. "We pick targets that are unique to the cancer and different from any normal part of the body, so the immune system can be effectively "steered" towards the cancer in a very specific way.
When the team initiated this study eight years ago, it wasn't clear whether this approach could work in kidney cancer. It had been shown to have the potential to be effective in melanoma, which has many more mutations and therefore many possible neoantigens.
Kidney Kidney Cancer Vaccine Carcinoma Cell Children Clinical Trial Efficacy Hospital Immune Response Immune System Immunotherapy Medical School Renal Cell Carcinoma Research Surgery Tumor
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