New dye offers breakthrough in deep tissue imaging and cancer therapy

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New dye offers breakthrough in deep tissue imaging and cancer therapy
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Researchers from Tokyo Metropolitan University have developed a new dye that can strongly absorb second near-IR radiation and transform it to heat.

Tokyo Metropolitan UniversityJan 25 2025 Starting with a dye from the bile pigment family, they designed a unique ring structure which can bind rhodium and iridium. Measurements and modeling revealed strong second near-IR absorptions and exceptional photostability. Second near-IR waves easily penetrate human tissue; the new dye may be applied in deep tissue therapies and imaging.

The efficacy of this approach hinges on the availability of stable contrast agents which can efficiently absorb light at these wavelengths. The majority of contrast agents, however, are more sensitive in the first near-IR range , where scattering effects are stronger, and energy delivery is less efficient.

The team's new dye showed its strongest light absorption at a wavelength of 1600 nanometers under normal conditions, which is well inside the second near-IR region. It was also shown to be very photostable, meaning that it won't break apart easily on exposure to light.

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