Research has revealed that infections treated by broad-spectrum antibiotics are associated with an increased risk of anxiety and depression. But, what’s the likelihood you may actually experience a mental wobble while on meds?
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MND cure 'possible' says expert as Doddie Weir charity launches research srategyThe Scottish rugby legend, who died in November following a six-year battle with MND, launched the My Name'5 Doddie Foundation in frustration at the lack of a cure and hope for those diagnosed with the condition.
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Three dietary factors most to blame for the increase in type 2 diabetes, research saysA study looks at data from 1990 and 2018 for an insight into which dietary factors are driving the increase in type 2 diabetes worldwide.
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Electronic cigarette menthol flavoring is associated with increased inhaled micro and sub-micron particles and worse lung function in combustion cigarette smokers - Respiratory ResearchFlavored electronic cigarettes (ECs) present a serious health challenge globally. Currently, it is unknown whether the addition of highly popular menthol flavoring to e-liquid is associated with changes in the number of aerosolized particles generated or altered lung function. Here, we first performed preclinical studies using our novel robotic platform Human Vaping Mimetic Real-Time Particle Analyzer (HUMITIPAA). HUMITIPAA generates fresh aerosols for any desired EC in a very controlled and user-definable manner and utilizes an optical sensing system to quantitate and analyze sub-micron and microparticles from every puff over the course of vaping session in real-time while emulating clinically relevant breathing mechanics and vaping topography. We discovered that addition of menthol flavoring to freshly prepared e-liquid base propylene glycol–vegetable glycerin leads to enhanced particle counts in all tested size fractions, similar to the effect of adding vitamin E acetate to e-liquid we previously reported. Similarly, we found that menthol vs. non-menthol (tobacco) flavored pods from commercially available ECs leads to generation of significantly higher quantities of 1–10 µm particles upon inhalation. We then retrospectively analyzed data from the COPDGene study and identified an association between the use of menthol flavored ECs and reduced FEV1% predicted and FEV1/FVC independent of age, gender, race, pack-years of smoking, and use of nicotine or cannabis-containing vaping products. Our results reveal an association between enhanced inhaled particle due to menthol addition to ECs and worse lung function indices. Detailed causal relation remains to be demonstrated in future large-scale prospective clinical studies. Importantly, here we demonstrate utility of the HUMITIPAA as a predictive enabling technology to identify inhalation toxicological potential of emerging ECs as the chemical formulation of e-liquid gets modified.
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Tory councils among worst-hit by cuts as party braces to lose 1,000 seats in local electionsTraditionally Tory seats among the worst hit in £2bn of cuts to local authority funding since 2016, Commons Library research shows.
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Prices of British food staples soar by up to 80 per cent - see full listThe price of British food staples, including cheddar cheese, white bread and porridge oats, have soared compared with one year ago, new research shows.
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