A genetic connection between cardiovascular disease and psoriasis highlights shared inflammatory pathways, emphasizing the need for cardiovascular monitoring.
By Pooja Toshniwal PahariaReviewed by Danielle Ellis, B.Sc.Sep 19 2024 New research reveals a genetic connection between cardiovascular disease and psoriasis, suggesting shared inflammatory mechanisms. The findings may guide future treatments for both conditions and underscore the importance of monitoring cardiovascular health in psoriasis patients.
Psoriasis is an excellent model for investigating this interaction since severe psoriasis is an independent risk factor for cardiovascular disease development. Cardiovascular risk factors, obesity, and dyslipidemia are common in the psoriasis community, particularly in those with severe cases. About the study In the present genetic association study, researchers examined the bidirectional links between genetic estimators of cardiovascular illness and IMIDs like psoriasis.
The primary study outcomes included the associations between genetic estimators of coronary artery disease and stroke and risks of psoriatic disease and nine other IMIDs. Mendelian randomizations with inverse variance weighting determined the associations. The data analysis period went from January 2023 until May 2024.
Results The analysis comprised 181,249 patients with CAD and 1,165,690 control individuals, 110,182 patients of stroke and 1,503,898 control individuals, and 36,466 patients of psoriasis and 458,078 control individuals among nearly 3,400,000 people. Contrasting prior assumptions, genetic estimators of psoriasis showed no relationship with stroke or CAD. Reverse association analyses showed that genetic estimators of stroke and CAD showed risk-enhancing relationships with psoriasis.
Sensitivity analyses and confounding adjustments produced similar findings. There were no differences in stroke or CAD Mendelian randomization effects on psoriasis between subgroups based on gender or HLA-C*06:02 status. Individuals on angiotensin-converting enzyme inhibitors, β-blockers, angiotensin receptor blockers , aspirin, or statins did not have increased effects on psoriasis from cardiovascular MR.
Psoriasis Angiotensin Arthritis Blood Cardiology Chronic Coronary Artery Disease Dyslipidemia Genetic Inflammation Inflammatory Bowel Disease Obesity Research Rheumatoid Arthritis Skin Skin Cells Stroke
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