Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unknown.
Compuscript LtdAug 29 2024 Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection is a fatal cardiovascular disease for which the key involved genes are largely unknown. The authors of this article aimed to identify promising AD biomarkers from high-throughput RNA expressing data.
In the GSE98770 dataset, differentially expressed mRNAs and microRNAs were identified through differentially expressed gene analysis and gene set enrichment analysis. The regulatory network between DE-mRNAs and DE-microRNAs was established, and hub genes were identified with Cytoscape. Relationships between hub genes and AD were confirmed in the Comparative Toxicogenomics Database . Potential key transcription factors were discovered with Cytoscape.
DE-mRNAs and DE-microRNAs were identified. Four mRNAs and microRNA-1321 were found to have the most connections with other genes. CBL was connected to the most genes and interacted with miR-1321, which was also connected to the most genes among the DE-microRNAs. In addition, CBL was associated with AD in the CTD. Among the top five transcription factors potentially regulating CBL transcription, only HOXB13 was a DE-mRNA. The findings were further successfully verified in human specimens.
CBL, which may be transcriptionally regulated by HOXB13 and post-transcriptionally regulated by miR-1321, was identified as the most promising potential biomarker for AD.Journal reference:https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0034
Genetic Microrna Cardiovascular Disease Gene Genes Transcription Transcription Factors
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