Cervicovaginal immune mediators demonstrate clear and consistent changes across the menstrual cycle, according to a Registered Report published in BMCMedicine.
. Two reviewers performed the assessments independently and then came to a consensus, with disagreements resolved by a third author .
We assigned an overall strength of evidence score to each immune mediator based on a four-star scale as follows: high , moderate , low , and very low .As part of this review and meta-analysis, we performed one additional study including an exploratory and a validation component. We used CVL samples from the Kenya Girls Study, a longitudinal cohort study of adolescent girls followed for acquisition of sexually transmitted infections [].
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