Choosing a cell culture method
Sponsored Content by Corning Life SciencesNov 16 2022Reviewed by Olivia Frost Cell cultures are valuable, and users desire them to grow under the finest conditions possible. So, when it comes to cell culture methods, should they opt for an adherent or a suspension platform? It all depends.
Most tissue-derived cells in the body require a surface or extracellular matrix to support growth and normal proliferation. Adherent cell culture platforms provide scalable options with increasing cell growth surface areas for production, and the option to utilize specialty surface chemistries and coatings that mimic a local microenvironment.” Visualization is also available on some adherent platforms.
However, the tradeoff may necessitate more effort up front. Scientists must modify cell types that depend on anchoring for suspension conditions. That requires time and work. However, not every program necessitates such a large scale. Autologous therapies and gene therapies for rare diseases or limited patient populations may be sufficiently produced on a lower scale.
Microcarriers, which use stirred-tank reactors, allow for better surface area to volume ratio scaling as well as pH and gas control. To take things a step further, fixed bed bioreactors and developing technology, like the Corning Ascent® Fixed Bed Reactor system, allow for a higher surface area to volume ratio while also immobilizing cells and decreasing the risk of shear stress.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
The do’s and don’ts of choosing a baby nameSearching for a baby name? Here's the do's and don'ts of picking a name for your new arrival.
Read more »
Ivanka Trump turns her back on her dad and won't support campaign for president'I love my father very much,' Ivanka Trump said. 'This time around, I am choosing to prioritize my young children.'
Read more »
I hated my wedding dress & had total regret - I just picked the first oneA BRIDE has admitted she had major regret over her wedding dress, after choosing one of the first ones she tried on. Felicity took to TikTok to share a video in which she explained her issues with …
Read more »
Choosing your platform for cell culture scale-up: suspension or adherent?When deciding on a cell culture method, two methods should be considered: cell suspension and adherent cell surface.
Read more »