Aggressive intravenous hydration increased the mortality risk in severe acute pancreatitis (AP) and fluid-related complication risk in both severe and non-severe AP, according to a study published in Crit_Care.
Current practice guidelines for optimal infusion rates during early intravenous hydration in patients with acute pancreatitis remain inconsistent. This systematic review and meta-analysis aimed to compare treatment outcomes between aggressive and non-aggressive intravenous hydration in severe and non-severe AP.This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
We included a total of 9 RCTs with 953 participants. The meta-analysis indicated that, compared to non-aggressive intravenous hydration, aggressive intravenous hydration significantly increased mortality risk in severe AP , while the result in non-severe AP was inconclusive . However, aggressive intravenous hydration significantly increased fluid-related complication risk in both severe and non-severe AP .
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