Researchers at Harvard T.H. Chan School of Public Health have created a comprehensive map of essential genes for blood infections in Plasmodium knowlesi, a parasite that causes malaria in humans. This map, the most complete classification of essential genes in any Plasmodium species, can help identify new drug targets and mechanisms of drug resistance, paving the way for the development of more effective malaria treatments.
Harvard T.H. Chan School of Public Health Feb 7 2025 A new, comprehensive map of all the genes essential for blood infections in Plasmodium knowlesi , a parasite that causes malaria in humans, has been generated by researchers at Harvard T.H. Chan School of Public Health and colleagues.
Manoj Duraisingh, co-corresponding author, John LaPorte Given Professor of Immunology and Infectious DiseasesEach year, around 249 million human cases of malaria are caused by a Plasmodium species, resulting in about 608,000 deaths. P. knowlesi is one of several species responsible for human malaria. It is a zoonotic parasite that can be lethal and is an emerging public health problem in Southeast Asia.
"Knowing all of the essential genes in P. knowlesi allows us to understand the molecular strategies that the parasite takes to grow, to respond to environmental changes, and to respond to therapeutics such as antimalarials," said co-first author Sheena Dass, postdoctoral fellow in the Department of Immunology and Infectious Diseases.
Brendan Elsworth and Sida Ye were co-first authors. Co-corresponding author was Kourosh Zarringhalam at the University of Massachusetts, Boston.
MALARIA DRUG RESISTANCE GENETICS PARASITES PUBLIC HEALTH
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