The second phase of the project is officially complete Grantham Lincolnshire
Lincoln City are hoping to make history and reach the League Cup 1/4 finals for the first time ever on Tuesday, facing Premier League opposition in the form of Southampton on the South Coast.
It’s been a very bright start to life at the Imps for Mark Kennedy. | Photo: Graham Burrell / Lincoln City FC An iconic FA Cup image showing Sean Raggett scoring the winning goal as Lincoln City beat Burnley to become the first non-league side to reach the quarter-final in over 100 years. | Photo: Chris Vaughan/Royal Mail
Football’s David vs Goliath. Arsenal vs Lincoln City in the FA Cup Quarter Final, March 2017. | Photo: The Lincolnite In August it was then Everton’s turn to travel to Lincoln, as the two sides met in the third round of the Carabao Cup at the LNER Stadium. Lincoln took a first-minute lead through Harry Anderson before Everton turned it round to 2-1, and Bruno Andrade fired a volley into the top corner to level the scores for the Imps.
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Population, Clinical, and Scientific Impact of National Cancer Institute's National Clinical Trials Network Treatment Studies | Journal of Clinical OncologyPURPOSE In the United States, the National Cancer Institute National Cancer Clinical Trials Network (NCTN) groups have conducted publicly funded oncology research for 50 years. The combined impact of all adult network group trials has never been systematically examined. METHODS We identified randomized, phase III trials from the adult NCTN groups, reported from 1980 onward, with statistically significant findings for ≥ 1 clinical, time-dependent outcomes. In the subset of trials in which the experimental arm improved overall survival, gains in population life-years were estimated by deriving trial-specific hazard functions and hazard ratios to estimate the experimental treatment benefit and then mapping this trial-level benefit onto the US cancer population using registry and life-table data. Scientific impact was based on citation data from Google Scholar. Federal investment costs per life-year gained were estimated. The results were derived through December 31, 2020. RESULTS One hundred sixty-two trials comprised of 108,334 patients were analyzed, representing 29.8% (162/544) of trials conducted. The most common cancers included breast (34), gynecologic (28), and lung (14). The trials were cited 165,336 times (mean, 62.2 citations/trial/year); 87.7% of trials were cited in cancer care guidelines in favor of the recommended treatment. These studies were estimated to have generated 14.2 million (95% CI, 11.5 to 16.5 million) additional life-years to patients with cancer, with projected gains of 24.1 million (95% CI, 19.7 to 28.2 million) life-years by 2030. The federal investment cost per life-year gained through 2020 was $326 in US dollars. CONCLUSION NCTN randomized trials have been widely cited and are routinely included in clinical guidelines. Moreover, their conduct has predicted substantial improvements in overall survival in the United States for patients with oncologic disease, suggesting they have contributed meaningfully to this nation's health. These find
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Construction of new Grantham relief road A1 connection completeThe second phase of the project is officially complete Grantham Lincolnshire
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