Researchers examined the link between mental illness and COVID-19 vaccine uptake, finding high vaccination rates but lower uptake among unmedicated individuals with mental health conditions.
By Pooja Toshniwal PahariaReviewed by Susha Cheriyedath, M.Sc.Oct 1 2024 Despite high overall vaccination rates, unmedicated individuals with mental illness show significantly lower COVID-19 vaccine uptake, signaling the need for targeted health interventions.
The coronavirus disease 2019 led to unprecedented morbidity and mortality globally. Despite the widespread distribution of effective COVID-19 vaccines internationally, vaccine hesitancy and rejection remain considerable. Achieving high vaccination coverage is critical for combating the pandemic. High-risk individuals, such as those suffering from mental illnesses, are more likely to get severe COVID-19 and die. However, research on COVID-19 vaccination uptake has had mixed outcomes.
Substance use disorder impact: Among mental illnesses, substance use disorder showed the strongest association with lower vaccine uptake, with a 16% reduction in first-dose acceptance compared to those without mental illness. The sensitivity analyses excluded electronic medical records for exposure and outcome definitions and individuals with chronic diseases. The studies explored differences related to nationwide COVID-19 vaccination policies and mitigation strategies. Poisson regressions indicated the prevalence ratios , adjusted for age, gender, comorbidities, smoking habits, and prior COVID-19 history. Random effects meta-analyses aggregated the results from the COVIDMENT cohorts.
The COVIDMENT results showed no link between depression or anxiety and vaccination uptake. However, the Swedish register data showed a nuanced picture, revealing that individuals with specialist-diagnosed depression had higher uptake of the first dose of the vaccine, but those with depression who were not taking medication had reduced uptake for the initial COVID-19 vaccination.
Vaccine Anxiety Coronavirus Depression Mental Disorder Mortality Pandemic Research Respiratory SARS SARS-Cov-2 Schizophrenia Severe Acute Respiratory Severe Acute Respiratory Syndrome Substance Use Disorder Syndrome
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