University of Sydney scientists have found a receptor protein which ‘acts a bit like molecular velcro, in that it sticks to the spike of the virus’
Australian researchers have found a protein in the lungs that sticks to the Covid-19 virus like velcro and immobilises it, which may explain why some peopleThe research was led by Greg Neely, a professor of functional genomics with the University of Sydney’s Charles Perkins Centre in collaboration with Dr Lipin Loo, a postdoctoral researcher and Matthew Waller, a PhD student.
LRRC15 is not present in humans until Sars-CoV-2 enters the body. It appears to be part of a new immune barrier that helps protect from serious Covid-19 infection while activating the body’s antiviral response. “When we look at lungs from patients that died of Covid there is much of this protein,” Neely said. “But we couldn’t look at the lungs of patients that survived Covid as lung biopsy is not something that is easy to do on live people. We predict there is more of this protein in survivors versus those that died of Covid.”
“Our data suggests that higher levels of LRRC15 would result in people having less severe disease,” Neely said.
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