A recent study published in JAMA Dermatology has found that maximizing cumulative isotretinoin dosage may significantly reduce acne recurrence and the need for retreatment, offering hope for long-term skin clarity.
A recent study published in JAMA Dermatology explored the factors influencing acne relapse after isotretinoin treatment. Isotretinoin, commonly known as Accutane, is the gold standard treatment for severe acne, but some patients experience recurrence. This research aimed to understand if patient characteristics, isotretinoin dosage, and treatment regimens affect acne relapse rates.
\The study analyzed data from the MarketScan commercial claims database between 2017 and 2020, including patients aged 12 years or older who received isotretinoin treatment for acne. Researchers defined acne relapse as a prescription for systemic acne treatment, including oral antibiotics or isotretinoin, within a certain timeframe after the completion of the initial isotretinoin course. \The analysis involved 1,856,012 patients, revealing that 12.9% experienced acne relapse per 100 person-years. Females had a significantly higher risk of relapse compared to males, with a 43% increased risk. Notably, the study found that higher daily doses of isotretinoin did not provide additional protection against relapse. However, cumulative dosage was significantly associated with a reduced rate of acne relapse. Approximately 8.2% of patients underwent isotretinoin retrial, with a median time of 2.8 months. \The findings suggest that maximizing cumulative isotretinoin dosage could significantly reduce acne recurrence and the need for retreatment, offering hope for long-term skin clarity. This knowledge can help clinicians tailor treatment regimens, manage patient expectations, and develop effective maintenance plans
ISOTRETINOIN ACNE RELAPSE DOSAGE TREATMENT JAMA DERMATOLOGY
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