Science, Space and Technology News 2024
Researchers have successfully reconstructed the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth, a breakthrough using ancient DNA preserved by freeze-drying. Credit: SciTechDaily.com
An international team of researchers has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth. This is the first time such a feat has been achieved for any ancientThe fossilized chromosomes, which are around a million times longer than most ancient DNA fragments, provide insight into how the mammoth’s genome was organized within its living cells and which genes were active within the skin tissue from which the DNA was extracted.
To reconstruct the mammoth’s genomic architecture, the researchers extracted DNA from a skin sample taken behind the mammoth’s ear. They used a method called Hi-C that allows them to detect which sections of DNA are likely to be in close spatial proximity and interact with each other in their natural state in the nucleus.“Imagine you have a puzzle that has three billion pieces, but you don’t have the picture of the final puzzle to work from,” says corresponding author Marc A.
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