A new paper titled 'Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease' has been published in Aging.
context, but inconsistently with the identification of health markers in a biological context.
To address these limitations, the researchers moved from predictions to measurement of biological age, focusing on the cytosines that on average remain invariable in their methylation through lifespan, postulated to be homeostatically vital. They established that dysregulation of such cytosines, measured as the sums of standard deviations of their methylation values, quantifies biological noise, which in their hypothesis is a biomarker of aging and disease.
"We term this approach a 'noise barometer'—the pressure of aging and disease on an organism," they explain. These noise-detecting cytosines are particularly important as sums of SD on the entire 450K DNAme array data yield a random pattern through chronology. Testing how many cytosines of the 450K arrays become noisier with age, the team found that the paradigm of DNAme noise as a biomarker of aging and disease remarkably manifests in approximately one-fourth of the total.
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