Researchers examine the association between prescriptions of diabetes drugs and the incidence of alcohol intoxication and opioid overdose.
By Dr. Priyom Bose, Ph.D.Reviewed by Benedette Cuffari, M.Sc.Oct 22 2024 A new study explores the potential of diabetes drugs like GLP-1 RA and GIP agonists to reduce opioid overdoses and alcohol intoxication in patients with substance use disorders, offering hope for new treatments in the fight against addiction.
Can diabetes drugs prevent opioid-related deaths? The opioid crisis in the United States was declared a public health emergency in October 2017, with over 70,000 individuals who died to due drug overdoses that year. Following coronavirus disease 2019 -related restrictions, the opioid crisis continued to worsen, with over 107,000 deaths attributed to overdoses in 2021.
The primary objective of the current study involved OUD and AUD patients to examine the strength of the association between incident opioid overdose and alcohol intoxication and GIP/GLP-1 RA prescriptions, respectively. A secondary objective was to consider patients with comorbid conditions including T2D, obesity, or both and assess the association between substance use outcomes and GIP/GLP-1 RA prescriptions.
Study findings Individuals with a GIP/GLP-1 RA prescription had an average age of about 58 years and were more likely to be female and partnered. Patients in the OUD cohort with GIP/GLP-1 RA prescriptions had a 7.1% history of opioid overdose as compared to 15.7% of those not prescribed these medications.
Patients with OUD and a GIP/GLP-1 RA prescription were associated with a 40% reduced rate of incident opioid overdose as compared to those without a prescription, regardless of the presence of comorbid conditions. Among those with T2D or obesity and a GIP/GLP-1 RA prescription, the rate of opioid overdose was 38% and 33% lower, respectively. For individuals with both T2D, obesity and a GIP/GLP-1RA prescription, the rate of opioid overdose was reduced by 35%.
Diabetes Drugs Intoxication Overdose Addiction Agonist Coronavirus Covid-19 GLP-1 Glucagon Glucagon-Like Peptide-1 Glucose Mental Health Obesity Public Health Receptor Tobacco
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