Review highlights how gut dysbiosis and dietary factors are linked to rheumatoid arthritis, influencing disease progression and inflammation. Researchers explore how specific diets may help modulate the gut microbiome to improve symptoms.
By Dr. Chinta SidharthanReviewed by Benedette Cuffari, M.Sc.Sep 29 2024 Recent research explores how gut microbiome imbalances contribute to rheumatoid arthritis , and how dietary interventions could be key to reducing inflammation and improving patient outcomes.
What causes rheumatoid arthritis? Rheumatoid arthritis, which affects approximately 0.5% of the global population, is an autoimmune disease that causes inflammation in the joints of the body, especially in the hands and feet. As a result, rheumatoid arthritis can severely impact mobility, cause disability, and reduce the overall quality of life. This disease can also manifest in symptoms other than joint pain and swelling, causing nodules in the skin and lung disease.
Previous studies have reported that the diversity of the gut microbiome is reduced in patients with rheumatoid arthritis. Increased abundance of Prevotella copri, for example, has been associated with new-onset rheumatoid arthritis cases. Similarities between P. copri and the molecules in the joint tissues also cause molecular mimicry, which can cause the immune system to attack cells in the joint tissues.
Related StoriesThe association between rheumatoid arthritis and the gut microbiome is further supported by the finding that immune cells such as T helper type 17 cells, which play a crucial role in rheumatoid arthritis progression, are negatively correlated with the abundance of bacteria like Firmicutes. Changes in the gut microbiome also impact how patients respond to immunotherapy and other rheumatoid arthritis treatments.
In contrast, diets consisting of saturated fats and red meat can worsen rheumatoid arthritis symptoms, as both of these dietary components increase inflammation, whereas saturated fats have been shown to alter the gut microbiome.
Diet Dysbiosis Rheumatoid Arthritis Autoimmune Disease Bacteria Disability Fatty Acids Immune System Inflammation Joint Pain Lung Disease Meat Microbiome Nutrients Pain Saturated Fats Skin
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