Macquarie University researchers have discovered new information about how oral cancer cells may block the body's immune response. This could lead to better treatments for this aggressive disease.
Macquarie UniversitySep 18 2024 Macquarie University researchers have discovered new information about how oral cancer cells may block the body's immune response. This could lead to better treatments for this aggressive disease.
We thought there might be proteins in oral cancer cells working together to reduce immune cell attack." Dr. Chakraborty is principal investigator of the project, and is also a dentoalveolar surgeon and a Macquarie University PhD graduate. The research focused on a protein called 'signal transducer and activator of transcription 3' – shortened to STAT3, which helps oral cancer cells grow. The team used advanced proteomic techniques to see which other proteins STAT3 interacts with in oral cancer cells.
"Human oral tissue cells are taken and prepared in such a way that the immune cells interact with oral cancer cells simultaneously to mimic tumour behaviour." Their analysis showed STAT3 and its partner proteins may be involved in pathways that help cancer avoid the immune system.
Immune System Oral Cancer Research Cancer Treatment Cell Cetuximab Immune Response Immunotherapy Protein Tongue
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