Does oral exposure to cannabidiol (CBD) have toxic implications? FDAfood oralexposure cbd CBD cannabidiol toxic implications research health
By Bhavana KunkalikarApr 25 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Food and Chemical Toxicology Journal, researchers reviewed the implications of oral exposure to cannabidiol .Background Recent studies suggest that CBD intake can lead to reproductive and developmental toxicity and hepatotoxicity in animal models. Several phylogenetically different animals have noted male reproductive toxicity due to CBD.
Toxicological profile of CBD Developmental and reproductive toxicity The team performed a 90-day oral toxicity assessment for CBD in Rhesus monkeys. Remarkable alterations were noted in organ weights in all CBD dose cohorts for both sexes; however, an obvious dose-response relationship was not noted for all organs.
Related StoriesYet, the liver weights were slightly high while the testes size was decreased by 20% to 25%. Additionally, the team noted no alterations in organ weights were related to any functional dysfunction, except for the testes. Furthermore, most epileptic patients with increased liver enzymes were also recommended other anti-epileptic therapeutics, like valproate, which also harbors a likelihood of increasing liver aminotransferase levels.
This occurred in a concentration- and time-dependent manner in the two cell types, with a 50% effective concentration . In mice subjects, intraperitoneal treatment with 10 mg/kg BW/day of CBD for five consecutive days elicited statistically remarkable elevations in the proportion of micronuclei in bone marrow erythrocytes compared to controls, with a remarked improvement during chromosomal abnormalities.
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