Researchers from The University of Texas MD Anderson Cancer Center have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more likely to benefit from adding the immunotherapy tremelimumab to a combination of durvalumab plus...
University of Texas M. D. Anderson Cancer CenterOct 9 2024 Research ers from The University of Texas MD Anderson Cancer Center have demonstrated that patients with metastatic non-squamous non-small cell lung cancer harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more likely to benefit from adding the immunotherapy tremelimumab to a combination of durvalumab plus chemotherapy to overcome treatment resistance typically seen in this patient population.
"STK11 and KEAP1 alterations are common in patients with NSCLC and are linked to poor clinical outcomes with current standard-of-care first-line treatments," said co-lead author Ferdinandos Skoulidis, M.D., Ph.D., associate professor of Thoracic/Head and Neck Medical Oncology "While prior research suggested potential benefits from adding CTLA-4 inhibitors to PD-1 or PD-L1 inhibitors, we have no reliable biomarkers to predict which patients would see the best outcomes.
Based on these observations, the researchers hypothesized that dual checkpoint inhibitors, targeting CTLA-4 in addition to PD-1 or PD-L1, may improve outcomes. In an analysis of 1,013 patients from the POSEIDON study, the researchers confirmed tremelimumab plus durvalumab and chemotherapy improved responses rates, progression-free survival and overall survival.
Chemotherapy Immunotherapy Lung Cancer Cell CTLA-4 Genes Neck Oncology PD-L1 Ph Preclinical Research Tumor
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