An emerging class of anticancer drugs called EZH2 inhibitors may greatly enhance the potency of some cancer immunotherapies, according to a preclinical study led by Weill Cornell Medicine lymphoma researchers.
Weill Cornell Medicine Dec 5 2024
Dr. Wendy Béguelin, senior author, John P. Leonard, MD/Gwirtzman Family Research Scholar in Lymphoma and an assistant professor of pharmacology in medicine at Weill Cornell Medicine This study proposed that inhibiting EZH2 might help enhance the potency and durability of these immunotherapies. EZH2 is an enzyme that normally helps program cell behavior by controlling the expression of specific genes. Mutations in the EZH2 gene, which makes the enzyme more active, are now recognized as common features of lymphomas, and inhibiting this enzyme has been found to benefit lymphoma patients even when they have non-mutant EZH2.
Suitable preclinical animal models to test this hypothesis have not been available, so Dr. Béguelin and her colleagues started by developing a new mouse model for follicular lymphoma and a tumor line for the more common and aggressive diffuse large B-cell lymphoma.
Antibody Bispecific Antibody Cancer Cell Enzyme Follicular Lymphoma Immunotherapy Lymph Node Lymphoma Medicine Preclinical Research T-Cell Tumor
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