The University of Alabama at Birmingham startup TIXiMED, Inc., has obtained clearance from the United States Food and Drug Administration to proceed to clinical trials under an Investigational New Drug for TIX100, its novel oral Type 1 diabetes drug.
University of Alabama at BirminghamJul 31 2024 This represents a major milestone in the development of this new approach to T1D treatment and gives TIXiMED the green light to start human studies with TIX100.
Anath Shalev, M.D., the Nancy R. and Eugene C. Gwaltney Family Endowed Chair in Juvenile Diabetes Research In diabetes, TXNIP, a protein involved in oxidative stress, is elevated in pancreatic islets and causes beta cell death and dysfunction. Shalev's research has shown that inhibiting TXNIP protects beta cells and promotes beta cell health and function.
Related StoriesThese beneficial effects of TXNIP inhibition were illustrated in different mouse models of diabetes as well as in humans with T1D, confirming the translatability of this approach. Using the same preclinical diabetes models, the Shalev Lab was able to test TIX100 and observed even more striking antidiabetic effects. These also included normalization of alpha cell glucagon secretion, a diabetes issue that is difficult to address.
Type 1 Diabetes Cell Endocrinology Food Glucose Insulin Juvenile Diabetes Medicine Metabolism Research
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