Exclusive: Mitochondrial donation treatment aims to prevent children from inheriting incurable diseases
in 2018. Approval is given on a case-by-case basis by the UK’s Human Fertilisation and Embryology Authority , which has given the green light for at least 30 cases.
The regulator said the number of births was “less than five” rather than giving the precise figure, because doing so “could lead to the identification of a person to whom the HFEA owes a duty of confidentiality”. The number was accurate as of late April 2023, it said. No further details of the births were provided.
The Newcastle process has several steps. First, sperm from the father is used to fertilise eggs from the affected mother and a healthy female donor. The nuclear genetic material from the donor’s egg is then removed and replaced with that from the couple’s fertilised egg. The resulting egg has a full set of chromosomes from both parents, but carries the donor’s healthy mitochondria instead of the mother’s faulty ones. This is then implanted in the womb.
after treating a Jordanian woman who carried mitochondrial mutations that cause a fatal condition called Leigh syndrome. Prior to the treatment, performed in Mexico, the woman had four miscarriages and two children. One died aged six, the other lived for only eight months.
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