Allergic diseases such as asthma, atopic dermatitis, and food allergies have been increasing in frequency over the last few years.
Tokyo University of ScienceDec 16 2024 Food allergies in particular affect millions of people worldwide-;this includes allergies to foods such as milk, peanuts, eggs and shellfish. They are typically caused by the immune system being hypersensitive to harmless substances in foods and the environment. Flavonoids are chemicals present in various fruits and vegetables that are known to have anti-allergic effects and show promise as natural allergic treatments.
This was the question answered by a group of researchers led by Professor Chiharu Nishiyama at the Tokyo University of Science , in a letter published online in Allergy on December 11, 2024. In their study, the authors screened around 40 different flavonoids to see if they increased RALDH2 levels in DCs. The most effective of these was a compound called kaempferol, which they chose to study further. The primary contributors to this study were Ms. Miki Takahashi, a 2023 graduate from TUS, Dr.
"In the past, we reported that PU.1 and IRF-4 were key molecules that regulated the Aldh1a2 gene in dendritic cells," says Prof. Nishiyama. "In this study, we found that PU.1 and IRF-4 expression and function were enhanced in dendritic cells stimulated with kaempferol," she further explains, elucidating the PU.1/IRF-4-dependent mechanism behind kaempferol's anti-inflammatory effects.
Anti-Inflammatory Asthma Atopic Dermatitis Cell Cell Development Chemicals Dermatitis Enzyme Food Frequency Gene Immune Response Immune System Immunology Inflammation Receptor Research Retinoic Acid T-Cell Technology Vegetables Vitamin A
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