From toad toxin to medicine: The promise of 5-MeO-DMT

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From toad toxin to medicine: The promise of 5-MeO-DMT
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The compound stands out for its quick and potent psychedelic effects. Can lab formulations help improve mental health?

ArticleBody:This article was originally featured on Undark. When Johannes Reckweg arrived in the Netherlands in 2016 to work on his master’s program in neuropsychology, he didn’t expect to learn about a psychedelic compound commonly found in a toad that lives half a world away. But his research on stimulants led him to another substance that quickly piqued his interest: 5-MeO-DMT.

Much of the synthetic research has focused on the psychoactive properties of 5-MeO-DMT, and little is known about how much those other components contribute to the effect. As with other psychedelics, exactly how all the involved mechanisms work is not fully understood. “The effects are so strong that the patient or participant is either unconscious or very vulnerable in that moment.

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