As an undergraduate student in The University of Texas at Arlington's Honors College, Hannah Selvarathinam knew she wanted to conduct research. Near the end of her first year at UTA, the Keller native reached out to the lab of biology Assistant Professor Piya Ghose.
Apr 30 2024University of Texas at Arlington As an undergraduate student in The University of Texas at Arlington's Honors College, Hannah Selvarathinam knew she wanted to conduct research. Near the end of her first year at UTA, the Keller native reached out to the lab of biology Assistant Professor Piya Ghose.
Ghose brought Selvarathinam in to work on one of the lab's core projects related to the genetics of cell death, modeled in the roundworm Caenorhabditis elegans. Selvarathinam's work eventually led to her honors thesis, focused on brain health and behavior. The result is a new peer-reviewed publication detailing the genes affecting worm behavior that also are relevant to neurological disease in humans.
"Normally, worms spend much of their time eating. But if they are interrupted by physical insult, they briefly stop in a manner similar to the startle response in humans," Selvarathinam said. "What we found in our study is that healthy worms, as expected, momentarily stopped eating when they were exposed to a stimulus, but soon continued to eat again," Selvarathinam explained. "But for worms with mutations in many of the neurodegeneration genes, such as with those related to hereditary spastic paraplegia and Alzheimer's disease, they continued to eat even after being exposed to the stimulus, which shows a heightened startle response.
Brain Disease Cell Cell Death Genes Genetics Neurodegeneration Neurodegenerative Disease Research Schizophrenia
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