People who experience an arterial ischemic stroke (AIS) or transient ischemic stroke (TIA) are at an increased risk of suffering a second stroke or other major adverse cardiovascular event (MACE), making it critically important to identify risk factors and treatments to prevent these subsequent occurrences.
University of BristolJul 22 2024 People who experience an arterial ischemic stroke or transient ischemic stroke are at an increased risk of suffering a second stroke or other major adverse cardiovascular event , making it critically important to identify risk factors and treatments to prevent these subsequent occurrences.
"While previous studies have found associations between inflammation and incident AIS/MACE, our study found that these causal proteins may also have a role in subsequent MACE, which could lead to potential novel drug targets," said study co-lead author Nimish Adhikari, a PhD student in biostatistics at BUSPH.
GWAS are typically performed to determine whether individuals have had a medical event for the first time, but applying this method to subsequent MACE events could shed novel insights about stroke progression, information that would be valuable for therapeutic drug identification, the researchers say.
Andrew Elmore explained: "We used that data to find if there were certain molecules that were associated with either incident or subsequent states.
Chromosome Disability Gene Genetic Heart Inflammation Ischemic Stroke Medical School Public Health Research
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